Discussion

Is Fildena 120 Mg metabolized in liver?

Fildena 120 mg contains sildenafil citrate, which is primarily metabolized in the liver. Here's how it is processed: The main liver enzyme responsible is CYP3A4. A smaller contribution comes from CYP2C9. Sildenafil is converted into an active metabolite that has similar effects but is less potent than the parent drug. Fildena 120 Mg drug and its metabolites are then eliminated mainly in the feces (via bile) and to a lesser extent in the urine. Why this matters Because sildenafil is metabolized by the liver: Liver impairment can slow its breakdown, leading to higher drug levels and an increased risk of side effects. Drugs that inhibit CYP3A4 (such as ketoconazole, itraconazole, erythromycin, clarithromycin, ritonavir, and cobicistat-containing medications) can significantly increase sildenafil concentrations. Drugs that induce CYP3A4 (such as rifampin, carbamazepine, phenytoin, and St. John's wort) can reduce sildenafil's effectiveness. About the 120 mg strength A 120 mg dose is higher than the usual recommended maximum dose of sildenafil for erectile dysfunction (100 mg taken no more than once daily). Higher doses may increase the likelihood of side effects such as headache, flushing, dizziness, low blood pressure, visual disturbances, and priapism (an erection lasting more than 4 hours). If you have liver disease or are taking medications that affect CYP3A4, it's important to discuss the appropriate sildenafil dose with your healthcare provider before using Fildena 120 mg.